The 26-year-old, who was at her Seattle home during the trial, has said she refuses to willingly return to Italy to serve her 28 year and 6 month sentence.
Speaking to the Guardian for a series of interviews that were filmed before Thursday's verdict, Knox said:
'I'm definitely not going back to Italy willingly. They'll have to catch me and pull me back kicking and screaming into a prison that I don't deserve to be in. I will fight for my innocence.'
This is the third time that American Knox and her ex-boyfriend, Raffaele Sollecito have faced trial over the murder of British Meredith Kercher, who was found stabbed to death at the student home she shared with Knox in Perugia in 2007.
Knox and Sollecito were originally found guilty of her murder in 2009, before being released after winning an appeal and having their conviction overturned in 2011.
However following yesterday's retrial, Knox may be extradited from the US to Italy to serve her sentence.
Harvard Law Professor Alan Dershowitz said that if her conviction is upheld by the supreme court in Italy, the United States will have little choice but to extradite her.
'The United States seeks extradition of more people than any country in the world. We’re trying to get NSA leaker Edward Snowden back and we’re not going to extradite someone convicted of murder?' he told NBC News.
'If that happened in the U.S., it wouldn't be double jeopardy,' he said.
Meanwhile Knox's family were in shock over the verdict.
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'Amanda's upset, we were all shocked and upset, but we're all ready to fight too,' said Knox's mother Edda Mellas to ABC News.
'Everyone in the family, everyone in the extended family are all ready to continue to fight for truth and fight for her freedom and it's not going to stop.'
'If you look at common sense, you look at evidence, you look at the fact that Amanda is nowhere in that room, then no, I wasn't expecting this, absolutely not," said her father Curt Knox.
'They got it right in the first appeals trial where they found her innocent and allowed us to bring her home. And this is totally wrong."
Talking to an American news station about Knox's likely plea of the American law of double jeopardy, former prosecutor Sean Casey said:
'She was once put in jeopardy and later acquitted. Under the treaty, extradition should not be granted.'
Italian Raffaele Sollecito, 29, was yesterday sentenced to 25 years in prison.
Although he has been ordered to surrender his passport Sollecito will remain free, pending an appeal.
Present at the trial in Perugia were Meredith's family.
Meredith’s brother Lyle said that the verdict was never going to be ‘a case of celebrating’, but it was ‘the best we could have hoped for’.
‘It's hard to sort of feel anything at the moment because we know realistically it's going to go to a further appeal by the defendants, probably sometime in spring, so I think we were already prepared for that before this evening's decision.
‘I think anybody would just need to read in detail or know what happened to her to then question themselves - could they ever forgive someone who did that to their sister or daughter?’
Yesterday's verdict comes after six years of trials and investigations have failed to clear up many mysteries surrounding the murder of Kercher, 21, who was found murdered in her bedroom in the picturesque town of Perugia.
Sollecito was this morning caught trying to flee from Italy near the Slovenian borders.