Fighter jets were scrambled this afternoon to escort the aircraft after its pilot failed to respond to communications.
FIGHTER JETS SCRAMBLED TO ESCORT PLANE INTO MANCHESTER AIRPORT
The fighter jet pilots saw the plane's pilot slumped over through the window of the cockpit, and it is believed he was unconscious.
The small plane, believed to be carrying two passengers, then rapidly descended, crashing into the ocean just north of the island of Jamaica.
WOMAN SHAMELESSLY POSES WITH WRECKAGE FROM MH17
It is believed the flight was from New York bound for Florida.
The fighter jets were scrambled at 3.30 UK time, but were forced to peel away from the aircraft when it drifted into restricted Cuban Airspace.
Both passengers and the pilot are unaccounted for at this stage.