Victorino Chua was found guilty of murdering two patients and poisoning others using insulin at the hospital in Stockport.
The father of two was handed a life sentence and must serve a minimum of 35 years behind bars.
Judge Mr Justice Openshaw said Chua was an “experienced nurse who used cunning” to poison those he was supposed to be caring for.
Officers working on the case described him as a “narcissistic psychopath”.
By injecting insulin into saline bags and ampoules, Chua, killed Tracey Arden, 44, and Derek Weaver, 83. stress of it was obviously a contributory factor to that.” people suffer”.
Gary Arden, whose sister Tracey was murdered by Chua, said he felt "surprisingly nothing" for his sister's killer.
Overall, Chua was convicted of two murders, 22 counts of attempted grievous bodily harm, one count of grievous bodily harm, seven attempts of administering poison and one count of administering poison.
In a letter found at Chua’s home during the investigation, a letter – written by Chua – said that he was “an angel turned into an evil person” and wrote that “there’s a devil in me”.
During the sentencing Chua showed no emotion.
Worryingly, further investigations also found there were discrepancies in Chua’s medical qualifications.
Stockport NHS Foundation Trust said in a statement: “Our thoughts have been with the victims and their families throughout this time.
“We know they have suffered great distress but hope this sentence helps provide some closure for them in terms of seeing that justice has been served.”