The fashion designer, 40, attended the event at London’s Coliseum with retired footballer David, 39.
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When her name was called out to cheers from the crowd, Victoria told guests: “We’ve come a long way since the Spice Girls dressing rooms days.”
In her usual humour, Victoria then said she didn’t know how Emma Bunton, Mel B, Geri Halliwell and Melanie C put up with her, adding she “could be a right pain in the butt”.
She said: "Wow, thank you. I am so so proud to be British and incredibly proud to have built my brand in the UK.
"David, you inspire me every day. You support me, you make this possible. I adore you and the children."
Taking to Twitter after the awards, Victoria posted a picture of her and David from the red carpet and wrote: “U inspire me every day x I love u,what an incredible evening x vb [sic]”
David had spent the day supporting his wife at her boutique on London’s Dover Street as she promoted World Aids Day.
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Victoria also thanked her team, tweeting: “Thank you to my wonderful team, I love u all so much x congratulations!!! X what a special night x vb [sic]”
She and David were joined at the awards by Kendall Jenner, Cara Delevingne, Harry Styles, Emma Watson and Anna Wintour, amongst others.