Since splitting from wife Kris in 2014, much has been written about Bruce’s more effeminate appearance - his hair being worn longer and his nails being painted.
But 39-year-old Brand has slammed those for picking on Jenner, speaking out on YouTube show Trews.
Bruce has caused speculation with his longer hair and more 'feminine' appearance
‘This is bullying. Stop. Stop. Bruce Jenner is a human being,’ he said.
‘Transphobia seems to be the most recent and encouraged form of prejudice, now that racism and homophobia are not tolerated.’
Kris and Bruce in a snap from 2004
Brand referenced a recent cover of a US magazine, which shows a retouched photo of Bruce, made up to look like a woman.
The comedian rounded off the piece with: ‘Do you think people should be judged until they’re driven into a hole, perhaps even to suicide? Let us know!’