Trevor Smith, also known as Trevor Hancock, was reported missing from his home in Wirksworth, Derbyshire, just before 10pm last night.
Concerned relatives have said that he has not been seen since Monday night.
The 42-year-old - who has starred in Emmerdale, Coronation Street, Hollyoaks, No Angels, and Sherlock Holmes - is described as white, with short dark hair and is clean shaven.
Trevor appeared in Coronation Street in 1999 as Mr Dolan - a valuer from estate agents Adam Wade & Co, who were selling the soap's shop, The Kabin.
He was reportedly last seen wearing blue jogging bottoms, a black padded jacket,with a green Parka over the top of it, and a maroon and grey woolly hat.
He currently has plaster casts on both his wrists.
Police are appealing to Trevor Smith -or anyone who has seen him - to contact Buxton Police Station on 101.