But this time the 28-year-old is swapping late night presenting for a brand new CBBC show called The Dengineers.
According to a source, Mark will begin filming the show next week and it will see him working with kids as they build their own places to hang out.
Mark currently presents Take Me Out: The Gossip, and has a regular radio show on Heart FM but not all of his endeavours have been as successful.
His own ITV2 series, Party Wright Around The World, was scrapped after the first series.
A source told the Mirror: "Mark is still a big name in TV, even if those formats didn't really work.
"He's always wanted to be a kids' TV presenter. He starts filming next month and can't wait."
And it seems Mark's new project is going to be a family affair, as sister Jessica, 29, is rumoured to be making an appearance on the show.
Will you and your little ones be tuning into Mark's new show?