In a recent episode of Keeping Up With The Kardashians, Khloe could be seen comforting her ex-husband on the phone following the death of his best friend Jamie Sangouthai, who passed away in June this year.
After the call ended, a visibly anxious Khloe revealed that she was terrified that Lamar - who she married in September 2009 - would go the same way as Jamie.
She said: “Lamar’s best friend since he’s been like 12, Jamie, just passed away unexpectedly. This is all just really upsetting.
"He’s distraught and devastated.”
Khloe continued: “Lamar has suffered so much loss in his life. I’m always going to be there for Lamar, especially when something as tragic as this happens.
“I’m really on high alert for Lamar, because anything, I think, will set him to spiral.
"That’s kind of the last thing I want for him.”
He was rushed to a hospital in Las Vegas, where he is said to be in a ‘critical condition’ and ‘fighting for his life’.
Brothel owner Dennis Hof, speaking to CNN, said: ”He doesn't look good.
"He doesn't look like he'll make it and if he does, he won't be the same."
Khloe, who has been in close contact with the star following their divorce earlier this year, is reportedly at his bedside.