The 30-year-old has made no secret of her own desire to become a mother, and thinks Kim needs to be more grateful for the things she has.
Kim, 34, is allegedly jealous of their other sister Kourtney, 35, who just gave birth to her third child with Scott Disick, 31, while she and Kanye, 37, are said to be struggling to conceive their second.
A source a US website: "Khloe would willingly give both her arms and legs to have a baby and a husband and she thinks Kim is totally misguided and missing the big picture.
"[She should thank her] lucky stars for what she already has right in front of her – Nori and Kanye."
Khloe's anger reportedly caused friction with the family over Christmas and is said to be tiring her out.
The source continued: "She's literally tired of Kim always playing the victim. And not only that, Khloe feels Kim's draining the family for emotional support and comfort and taking the fun and joy out of Christmas and the New Year."
While she and Kanye long for a second child, Kim is finding Kourtney hard to deal with.
"Kourtney basically can blink and have a baby, and now Kim is having trouble she is extremely jealous and is not hiding her emotions about it to Kourtney," an insider added.