The 39-year-old is a Unicef ambassador and, as part of his role, he will film the adverts teaching the ways in which to stop the spreading.
In West African countries Sierra Leone, Liberia and Guinea alone the death toll from Ebola has risen to 4,033.
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Retired footballer David will stress the importance of cleanliness as the epidemic grips the continent.
Sierra Leone FA president Isha Johansen revealed David's role to The Sun, saying: "To have David Beckham involved in this campaign is massive for us and we are so grateful to him. In Sierra Leone football is a religion.
"All men, women and children follow a player or team from the Premier League but David Beckham is the favourite."
She added: "Our country and the whole of West Africa is facing a terrible plight and the numbers who are dying are incredible."
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David previously visited Makeni, Sierra Leone in 2008, which is one of the areas worst affected by Ebola, and where many of the victims there have been children.
While there he worked to raise global awareness on child survival, and how the high death rate in under fives there could be reduced.
Mrs Johansen said: "[David's] sympathetic message will be broadcast across the country and whole of West Africa, and it will raise the importance of how to fight this disease by simple things like good cleanliness."
During his work as a Unicef ambassador, David has also travelled to Philippines to meet children affected by Typhoon Haiyan.