The 65-year-old Keeping up with the Kardashians star is said to have smashed his Cadillac Escalade into the back of a white Lexus, the driver of which then veered into oncoming traffic and died.
Five children were also said to have been involved in the four car pile up that ensued in Malibu on Saturday.
The Kardashian family member was unhurt in the incident.
According to witnesses who spoke to entertainment site TMZ, Bruce hit the back of a Lexus at around midday on Saturday, which caused the vehicle to veer into oncoming traffic.
The three surviving drivers, including Jenner, are said to be co-operating with enquiries.
Spokespeople for the Jenner family say that several papparazi photographers were chasing Bruce at the time of the crash, though law officials have now said they were not responsible for the collision.
Jenner is also said to have passed a sobriety test on site.
An eyewitness said: ‘Bruce Jenner in bad accident on PCH in Malibu. He’s aight, but others involved not so much.’
We will keep you updated on this story as it develops.