At 6.45am a car and a coah collided on the M1, near Flitwick in Bedfordshire. The three men in the car were pronounced dead while another has been taken to hospital.
Police confirmed nobody in the coach was injured. A spokesman said: "Police are liaising with next of kin, a full collision and diversions are expected to remain in place for the next few hours."
The hatchback car was stationary on the hard shoulder when the double-decker coach collided with it.
Meanwhile just an hour later at 7.45am on the M40 in Oxfordshire, more than 40 vehicles were involved in a massive pile-up.
One person has been confirmed dead, while another is said to have life-threatening injuries. More than 50 others were left injured after the crash.
An ambulance spokeswoman told the Mirror: "It is quite a major collision. We were called at 7.48am to reports of a multiple road traffic collision on the M40, junctions 9 to 10 northbound.
"I understand that there are about 30 vehicles involved. We are currently assessing in excess of 30 patients.
"We have a lot of resources on the scene – ambulances, our helicopter ambulance, rapid response vehicles, our doctor and our hazardous area response team.
"Fire and police are also at the scene."