The family of the author revealed the tragic news in a statement, which read: "It is with tremendous sadness that we announce the death of our beautiful, dynamic and one-of-a-kind mother."
People magazine reported that Jackie was diagnosed with breast cancer six-and-a-half years ago.
"She was a true inspiration," the statement continued. "A trailblazer for women in fiction and a creative force. She will live on through her characters but we already miss her beyond words."
Jackie's sister Joan, 82, pad tribute to her, telling People: "She was my best friend. I admire how she handled this. She was a wonderful, brave and a beautiful person and I love her."
Mother-of-three Jackie, who was born in Hampstead, is one of the world's best-selling authors, having sold over 500 million copies in 40 countries.
She is famed for pushing the boundaries when writing fiction, and her first novel, The World Is Full of Married Men, released in 1968, was banned in Australia.
Speaking to the Mirror in 2010, Jackie revealed what she thought made her books so popular with women.
She said: "The fantasies I write are honest. A lot of the men I write are every woman's fantasy because they are sexy, but also nice. But not too nice. They've also god a bad-boy streak, but not too bad.
"And that's what every woman wants, including myself. I've always liked to have men with a bad-boy streak, otherwise it's boring."